Research Article
TLR3 Serves as a Prognostic Biomarker and Associates with Immune Infiltration in the Renal Clear Cell Carcinoma Microenvironment
Table 3
Correlation analysis between TLR3 and gene biomarkers of immune cells in KIRC (TIMER).
| Description | Biomarkers | None | Purity | Cor | value | Cor | value |
| CD8+ T-cells | CD8A | 0.232 | | 0.213 | | CD8B | 0.191 | | 0.171 | |
| T-cells (general) | CD3D | 0.134 | | 0.116 | | CD3E | 0.161 | | 0.141 | | CD2 | 0.221 | | 0.209 | |
| B-cells | CD19 | −0.087 | | −0.117 | | CD79A | −0.045 | 0.305 | −0.09 | 0.0526 |
| Monocyte | CD86 | 0.351 | | 0.349 | | CD115 (CSF1R) | 0.328 | | 0.302 | |
| TAM | CCL2 | 0.085 | | 0.093 | | CD68 | 0.359 | | 0.317 | | IL10 | 0.292 | | 0.267 | |
| M1 macrophages | INOS (NOS2) | 0.308 | | 0.263 | | IRF5 | 0.106 | | 0.085 | 0.0678 | COX2 (PTGS2) | 0.069 | 0.111 | 0.086 | 0.0649 |
| M2 macrophages | CD163 | 0.423 | | 0.392 | | VSIG4 | 0.257 | | 0.203 | | MS4A4A | 0.363 | | 0.343 | |
| Neutrophils | CD66b (CEACAM8) | 0.114 | | 0.104 | | CD11b (ITGAM) | 0.347 | | 0.328 | | CCR7 | 0.161 | | 0.125 | |
| Natural killer cells | KIR2DL1 | 0.174 | | 0.144 | | KIR2DL3 | 0.152 | | 0.125 | | KIR2DL4 | 0.091 | | 0.084 | 0.0714 | KIR3DL1 | 0.215 | | 0.189 | | KIR3DL2 | 0.138 | | 0.122 | | KIR3DL3 | 0.033 | 0.446 | 0.045 | 0.339 | KIR2DS4 | 0.116 | | 0.107 | |
| Dendritic cells | HLA-DPB1 | 0.372 | | 0.354 | | HLA-DQB1 | 0.299 | | 0.276 | | HLA-DRA | 0.463 | | 0.452 | | HLA-DPA1 | 0.474 | | 0.473 | | BDCA-1 (CD1C) | 0.217 | | 0.184 | | BDCA-4 (NRP1) | 0.543 | | 0.51 | | CD11c (ITGAX) | 0.048 | 0.267 | 0.049 | 0.292 |
| Th1 | T-bet (TBX21) | 0.164 | | 0.139 | | STAT4 | 0.206 | | 0.187 | | STAT1 | 0.495 | | 0.479 | | IFN-g (IFNG) | 0.173 | | 0.156 | | TNF-a (TNF) | 0.133 | | 0.102 | |
| Th2 | GATA3 | −0.068 | 0.119 | −0.053 | 0.26 | STAT6 | 0.45 | | 0.435 | | STAT5A | 0.307 | | 0.304 | | IL13 | −0.089 | | −0.079 | 0.09 |
| Tfh | BCL6 | 0.179 | | 0.166 | | IL21 | 0.001 | 0.989 | −0.018 | 0.698 |
| Th17 | STAT3 | 0.563 | | 0.539 | | IL17A | −0.055 | 0.207 | −0.037 | 0.425 |
| Treg | FOXP3 | 0.054 | 0.214 | 0.039 | 0.404 | CCR8 | 0.293 | | 0.289 | | STAT5B | 0.63 | | 0.618 | | TGFb (TGFB1) | 0.167 | | 0.146 | |
| T-cell exhaustion | PD-1 (PDCD1) | 0.07 | 0.107 | 0.054 | 0.243 | CTLA4 | 0.101 | | 0.096 | | LAG3 | 0.083 | 0.0555 | 0.07 | 0.135 | TIM-3 (HAVCR2) | 0.413 | | 0.393 | | GZMB | −0.016 | 0.706 | −0.055 | 0.237 |
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