Molecular Alterations of Circulating Cell-Free DNA in the Pathological Progression of Hepatocellular Carcinoma

Figure 1

The molecular profile of plasma cfDNA among CHB, LC, and HCC patients. Significantly mutated genes were detected in plasma cfDNA of patients with CHB, LC, and HCC and were ranked in order of decreasing mutation frequency. CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma; and MMB: molecular mutation burden. Mutation burden of HCC-related genes increased from CHB and LC to HCC.