Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma

Figure 2

Consensus clustering analysis of prognostic ferroptosis-related genes (FRGs) in melanoma. (a) Unsupervised clustering of prognostic FRGs to classify patients into two groups in TCGA-SKCM. (b) Unsupervised clustering of prognostic FRGs in GSE19345. (c) Unsupervised clustering of prognostic FRGs in GSE65904. Heat maps manifested the correlation between the expression of FRGs and the clinical characteristics of the two melanoma clusters: cluster A (blue) and cluster B (orange). The color codes for different clinical parameters are as indicated. Red color indicates upregulation of FRGs, and blue color refers to downregulation of FRGs. (d) Kaplan–Meier (KM) analysis of cluster A and cluster B in TCGA-SKCM with log-rank . (e) KM analysis of cluster A and cluster B in GSE19345 with log-rank . (f) KM analysis of cluster A and cluster B in GSE65904 with log-rank . (g) Principal component analysis (PCA) of prognostic FRGs expression profiles in TCGA-SKCM, GSE19345, and GSE65904 datasets, which illustrated distinct two clusters, cluster A (in red) and cluster B (in green).

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