Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma

Figure 6

Tumor infiltrating landscape between high and low ferroptosis-related genes (FRGs) score groups in TCGA-SKCM. (a) The landscape of immune infiltration between high- and low-FRGs score groups. (b) Heat map of correlation analysis for the FRGs score and immune infiltrating cells. (c) The subgroup analysis of 22 immune infiltrating cells between high- and low-FRGs score groups. (d) The correlation analysis between FRGs score and the expression of immune checkpoints. (e) The subgroup analysis of immune checkpoints between high- and low-FRGs score groups; . (f) Cancer hallmark enrichment plots showed that allograft rejection, coagulation, epithelial-mesenchymal transition, inflammatory response, and TNFA signaling via NFKB were active in the low-FRGs score group. (g) KEGG enrichment plots manifested that arachidonic acid metabolism, complement and coagulation cascades, cytokine-cytokine receptor interaction, ECM receptor interaction, and hematopoietic cell lineage were active in the low-FRGs score group.

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