Identification of a Ten-Gene Signature of DNA Damage Response Pathways with Prognostic Value in Esophageal Squamous Cell Carcinoma
Table 1
Univariable and multivariable Cox regression analyses to identify independent prognostic predictors in the GSE53625 cohorts.
Characteristics
Size
Uni-Cox analysis
aMulti-Cox analysis
bMulti-Cox analysis
HR (95% CI)
value
HR (95% CI)
value
HR (95% CI)
value
Age
≥60 vs. <60
179
1.58 (1.07–2.31)
0.0240
1.43 (0.97–2.1)
0.0709
1.57 (1.06–2.34)
0.0235
Sex
Male vs. female
179
0.78 (0.49–1.25)
0.3070
Grade
Moderately vs. well
130
1.01 (0.59–1.75)
0.9620
0.78 (0.44–1.37)
0.3810
Poorly vs. well
81
1.65 (0.93–2.96)
0.0900
1.09 (0.60–1.99)
0.7750
Stage
II vs. I
179
2.15 (1.45–3.21)
0.00015
2.26 (1.51–3.38)
<0.0001
2.30 (1.51–3.51)
0.00011
Location
Middle vs. upper
117
0.68 (0.39–1.20)
0.1850
0.64 (0.36–1.16)
0.1400
Lower vs. upper
82
0.60 (0.33–1.11)
0.1010
0.49 (0.26–0.95)
0.0338
Tobacco
Yes vs. no
179
0.75 (0.51–1.10)
0.1450
Alcohol
Yes vs. no
179
0.86 (0.59–1.27)
0.4550
DRGS
High vs. low
179
2.57 (1.75–3.77)
<0.0001
2.67 (1.80–3.94)
<0.0001
2.52 (1.69–3.75)
<0.0001
a: variables in multi-Cox analysis were selected by ; b: variables in multi-Cox analysis were selected by and clinical expertise; HR: hazard ratio, CI: confidence interval, DRGS : DDR-related gene expression signature.
