Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines

<div>HHT synergized with gilteritinib to suppress cell viability and induced apoptosis in FLT3-ITD mutant cell lines. (a) Cell viability of MV4-11 cells after treating with gilteritinib and HHT for two days, with CI values mentioned below the figure. (b) Cell viability of Molm13 cells after treating with gilteritinib and HHT for 48 hours, with CI values listed under the figure. (c, d) Apoptosis rates of MV4-11 cells (c) and Molm13 cells (d) treated with gilteritinib and/or HHT for 48 hours. DMSO-treated cells served as a control. Then, costaining of cells was done with annexin-V and PI, and the measurement of apoptosis was done by flow cytometry (e). 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Journal of Oncology

fig1

Figure 1

Figure 1: Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines 

Figure 1 | Homoharringtonine Synergized with Gilteritinib Results in the Downregulation of Myeloid Cell Leukemia-1 by Upregulating UBE2L6 in FLT3-ITD-Mutant Acute Myeloid (Leukemia) Cell Lines 