An Immune-Related Prognostic Signature for Predicting Clinical Outcomes and Immune Landscape in IDH-Mutant Lower-Grade Gliomas

Figure 1

The study process of constructing a six-gene immune-related risk signature. (a) Flowchart of data analysis for screening immune-related prognostic genes. (b, c) The Venn diagram for the overlapped genes of HR > 1 and HR < 1 between the CGGA_693 and TCGA cohorts. (d, e) LASSO Cox regression identified 14 genes related to OS in the CGGA_693 cohort. (f) Coefficient values by multivariate Cox for six selected genes. (g, h) Functional annotation of 105 candidate immune genes using GO terms of biological processes and KEGG terms. CGGA: Chinese glioma genome atlas; TCGA: the cancer genome atlas; OS: overall survival; HR: hazard ratio; IPS: immune-related prognostic signature.

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