HLA-DRB116:01 and HLA-DQB105:02 Alleles Influence the Susceptibility and Progression of Cutaneous Malignant Melanoma

Table 3

Most frequent HLA class II alleles with the patient cohort.

HLA-DRB1	Healthy donor (N = 1272), n (AF)	Melanoma patient (N = 474), N (AF)	HLA-DQB1	Healthy donor (N = 1272), n (AF)	Melanoma patient (N = 474), N (AF)
DRB101:01	103 (0.081)	36 (0.076)	DQB102:01	149 (0.117)	58 (0.122)
DRB101:02	41 (0.032)	14 (0.03)	DQB102:02	176 (0.138)	76 (0.16)
DRB101:03	12 (0.009)	4 (0.008)	DQB103:01	228 (0.179)	88 (0.186)
DRB103:01	148 (0.116)	57 (0.12)	DQB103:02	117 (0.092)	28 (0.059)
DRB104:01	36 (0.028)	16 (0.034)	DQB103:03	43 (0.034)	12 (0.025)
DRB104:02	24 (0.019)	4 (0.008)	DQB103:04	3 (0.002)	1 (0.002)
DRB104:03	37 (0.029)	2 (0.004)	DQB103:05	4 (0.003)	1 (0.002)
DRB104:04	32 (0.025)	15 (0.032)	DQB103:19	1 (0.001)	0 (0)
DRB104:05	15 (0.012)	7 (0.015)	DQB104:02	37 (0.029)	10 (0.021)
DRB104:06	2 (0.002)	2 (0.004)	DQB105:01	183 (0.144)	62 (0.131)
DRB104:07	20 (0.016)	1 (0.002)	DQB105:02	25 (0.02)	23 (0.049)^b
DRB104:08	0 (0)	2 (0.004)	DQB105:03	36 (0.028)	9 (0.019)
DRB107:01	210 (0.165)	80 (0.169)	DQB106:01	14 (0.011)	9 (0.019)
DRB108:01	29 (0.023)	10 (0.021)	DQB106:02	116 (0.091)	41 (0.086)
DRB108:02	3 (0.002)	1 (0.002)	DQB106:03	92 (0.072)	33 (0.07)
DRB108:03	2 (0.002)	0 (0)	DQB106:04	36 (0.028)	18 (0.038)
DRB108:04	2 (0.002)	0 (0)	DQB106:09	12 (0.009)	4 (0.008)
DRB108:06	3 (0.002)	0 (0)
DRB109:01	8 (0.006)	5 (0.011)
DRB110:01	25 (0.02)	8 (0.017)
DRB111:01	84 (0.066)	28 (0.059)
DRB111:02	16 (0.013)	5 (0.011)
DRB111:03	10 (0.008)	1 (0.002)
DRB111:04	39 (0.031)	22 (0.046)
DRB112:01	13 (0.01)	7 (0.015)
DRB113:01	94 (0.074)	34 (0.072)
DRB113:02	49 (0.039)	22 (0.046)
DRB113:03	21 (0.017)	6 (0.013)
DRB113:05	3 (0.002)	2 (0.004)
DRB114:01	32 (0.025)	9 (0.019)
DRB114:04	5 (0.004)	1 (0.002)
DRB115:01	121 (0.095)	44 (0.093)
DRB115:02	16 (0.013)	8 (0.017)
DRB115:03	1 (0.001)	0 (0)
DRB116:01	16 (0.013)	19 (0.04)^a

AF: allele frequency; n: number of observed alleles. ^aControl vs. melanoma patients: , Pc = 0.035, and OR = 3.28. ^bControl vs. melanoma patients: , Pc = 0.017, and OR = 2.54.