Knockdown of DIAPH3 Inhibits the Proliferation of Cervical Cancer Cells through Inactivating mTOR Signaling Pathway

Figure 1

DIAPH3 was overexpressed in cervical cancer and showed a poor prognosis. (a) The volcano map of differential genes in cervical cancer in TCGA database. Fold change >2, value < 0.01. (b) DIAPH3 was overexpressed in cervical cancer by analysis of TCGA data. (c) High expression of DIAPH3 displayed a poor overall survival in TCGA database. (d) The expression of DIAPH3 in cervical cancer according to GEPIA database. (e, f) The overall survival rates of DIAPH3 in GEPIA database and The Protein Atlas, respectively. (g) DIAPH3 was upregulated in CC cells compared with HaCaT. (h, i) The relative expression of DIAPH3 after transfection of si-NC and si-DIAPH3 in HeLa and Siha cells by qRT-PCR. (j, k) The relative expression of DIAPH3 after transfection of si-NC and si-DIAPH3 in HeLa and Siha cells by western blot. β-Actin was used as an internal control.

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