Trends in Incidence and Survival of Patients with Pancreatic Neuroendocrine Neoplasm, 1987–2016

Table 2

Summary data for Cox regression analysis of survival in patients with pNEN from 1987 to 2016 at nine SEER sites.

Variable	Relative risk (95% CI)	value
All 1987–1996
Univariate
Sex	1.035 (0.678–1.582)	0.873
Age	1.030 (1.013–1.047)	0.001
Race	1.144 (0.527–2.481)	0.734
SES	1.173 (0.749–1.836)	0.486
Grade	1.576 (1.194–2.080)	0.001
Multivariate
Age	1.024 (1.006–1.041)	0.007
Grade	1.404 (1.051–1.877)	0.022
All 1997–2006
Univariate
Sex	0.714 (0.528–0.966)	0.029
Age	1.030 (1.019–1.042)	<0.001
Race	1.633 (1.067–2.499)	0.024
SES	1.112 (0.823–1.502)	0.490
Grade	1.904 (1.573–2.305)	<0.001
Multivariate
Sex	0.856 (0.631–1.169)	0.333
Age	1.034 (1.023–1.046)	<0.001
Race	2.064 (1.331–3.198)	0.001
Grade	1.920 (1.582–2.330)	<0.001
All 2007–2016
Univariate
Sex	0.603 (0.462–0.786)	<0.001
Age	1.042 (1.032–1.053)	<0.001
Race	0.960 (0.658–1.400)	0.832
SES	1.344 (1.041–1.736)	0.023
Grade	2.584 (2.206–3.027)	<0.001
Multivariate
Sex	0.578 (0.442–0.754)	<0.001
Age	1.036 (1.026–1.047)	<0.001
SES	1.440 (1.114–1.862)	0.005
Grade	2.400 (2.045–2.817)	<0.001

Abbreviations: 95% CI, 95% confidence interval; SES, socioeconomic status.