The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis

Figure 3

THBSs’ methylation and distribution in cancer samples. (a) Bubble map of the differential methylation of THBS genes between TCGA cancer and normal samples. Blue dots indicate methylation downregulation in tumors, and red dots represent methylation upregulation in tumors. (b) The correlation between methylation level and THBS expression levels in TCGA cancer. (c) The relations of high or low methylation of THBS genes with overall survival in TCGA cancers. Only relations with value < 0.05 are displayed on the diagram. Red dots indicate that hypermethylation predicts worse survival in tumors, while blue dots represent the opposite. (d) Global percentage map shows the percentage of the gene’s function (activation or inhibition) for each pathway in all cancers. (e) Heatmap displaying the predicted drug sensitivity of cancers with upregulated THBSs expression.

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