The Integrative Analysis of Thrombospondin Family Genes in Pan-Cancer Reveals that THBS2 Facilitates Gastrointestinal Cancer Metastasis

Figure 4

Upregulation of THBS2 mRNA expression is associated with the progression of gastric, colon, and pancreatic cancer. (a) The expression level of THBS2 in COAD, STAD, PAAD, and corresponding normal tissues. (b) The relationships of THBS2 with THBS1, THBS3, THBS4, and THBS5 in COAD, STAD, and PAAD. (c) Overall survival curve of THBS2 in the colon, gastric, and pancreatic cancer. (d) Disease-free survival curve of THBS2 in COAD. (e) Venn diagram displaying the overlapped genes among THBS2-coexpressed genes in COAD, STAD, and PAAD. (f) Visualization of protein-protein interaction (PPI) networks for the top 15 hub overlapped genes from (e). (g) The relationships of hub genes (COL1A2, BGN, POSTN, COL1A1, COL5A2, COL6A1, and COL12A1) and overall survival in STAD, COAD, or PAAD.

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