MiR-145-5p Inhibits the Invasion of Prostate Cancer and Induces Apoptosis by Inhibiting WIP1

<div>Overexpression of miR-145-5p inhibits the PI3K/AKT signaling pathway and upregulates ChK2 and p-p38MAPK expression. (a) Western blot analysis of PI3K, p-PI3K, AKT, p-AKT, ChK2, Total p38MAPK and p-p38MAPK. MiR-145-5p overexpression had no significant effect on the total PI3K and AKT, while inhibition of the expression of p-PI3K and p-AKT. (b) Statistical analysis results of each group of proteins. (c) Western blot analysis of Bax, Bcl2 and Cleaved Caspase 3. 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Journal of Oncology

fig3

Figure 3

Figure 3: MiR-145-5p Inhibits the Invasion of Prostate Cancer and Induces Apoptosis by Inhibiting WIP1 