Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

Figure 6

CA inhibits the migration and invasion of KYSE-150 cells via suppressing the MAPK signaling pathway. (a) CA dose-dependently inhibits cell migration as evaluated by Transwell assay. (b) Quantification of cell migration in the Transwell assay in (a). (c) CA dose-dependently decreases the expression E-cadherin and simultaneously increases the expression of N-cadherin, respectively, by Western blot. (d) CA dose-dependently decreases the levels of p-JNK, p-ERK, and p-38 but does not affect those of total JNK, p-38, and ERK by Western blot.

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