Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Cell lines/compounds</td><td class="align_center" colspan="2">IC50 (<i>μ</i>M)</td></tr><tr class="thead"><td class="align_center">MIHA</td><td class="align_center">KYSE-150</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Carnosic acid</td><td class="align_center">&gt;200</td><td class="align_center">29.87 ± 4.38</td></tr><tr><td class="align_left">5-Fluorouracil</td><td class="align_center">&gt;200</td><td class="align_center">65.98 ± 1.39</td></tr><tr><td class="align_left">DDP</td><td class="align_center">16.64 ± 0.39</td><td class="align_center">79.21 ± 2.02</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>IC50 (<i>μ</i>M) values were drug concentrations necessary for 50% inhibition of cell viability. Data are presented as “mean ± SD” from at least three independent experiments in triplicates. The drug treatment period was 48 h.<br/></div></td></tr></table>

<div><i>IC</i>50 (<i>μ</i>M) values were determined via the MTT assay.</div>

Journal of Oncology

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Table 1

Table 1: Carnosic Acid Induces Antiproliferation and Anti-Metastatic Property of Esophageal Cancer Cells via MAPK Signaling Pathways 