Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3β/Tyr216 Accumulation

Figure 1

Low-dose albendazole (ABZ) treatment effectively inhibits the migration and invasion of melanoma cells. (a) The chemical structure of ABZ. (b-c) The A375 and B16-F10 cells were treated with or without different concentrations of ABZ. CCK-8 analysis was performed to detect cell viability and proliferation. (d–e) The A375 and B16-F10 cells were treated with different concentrations of ABZ (0.1, 0.2, and 0.4 μM). The wound healing area and relative wound closure rate (%) in melanoma cells were measured and analyzed 24 h after treatment. (f-g) The inhibitory effect of ABZ on the invasion of A375 and B16-F10 cells was detected using transwell experiments. The data are expressed as means ± SD. All experiments were performed thrice. ; .

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