Low-Dose Albendazole Inhibits Epithelial-Mesenchymal Transition of Melanoma Cells by Enhancing Phosphorylated GSK-3β/Tyr216 Accumulation

Figure 2

ABZ treatment suppresses lung melanoma metastasis in mice. (a) Representative image and (b) statistical analysis of luminescence intensity in B16-F10-luc tumor-bearing nude mice treated with different concentrations of ABZ (n = 5). (c) The upper, middle, and lower panels represent the melanoma nodules on the lung surfaces of mice in the control, 20 mg/kg ABZ, and 50 mg/kg ABZ groups, respectively. (d) Scores of the melanoma nodules in each experimental group. The scoring criteria for tumor nodule diameter were as follows: Level 1: <0.5 mm; Level 2: >0.5 mm, <1.0 mm; Level 3: >1.0 mm, <2.0 mm; and Level 4: >2 mm. (e) Representative images of HE stained mice lung sections from the control and ABZ-treated groups. The circled parts show the lung metastatic nodules. All animal experiments were repeated thrice. .

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