CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression

<div>circANXA2 is upregulated in lung cancer tissues and is related to the prognosis of lung cancer patients. (a) qRT-PCR was used to detect the expression of circANXA2 in tumor tissues and adjacent tissues of lung cancer patients. (b) Ki-67 is positively correlated with circANXA2. (c) CircANXA2 is upregulated in lung cancer cell lines. (d) FISH assay was used to detect the expression and location of circANXA2 in cells. <sup>∗</sup><i>P</i> <span class="nowrap"><svg height="8.98582pt" id="M2" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.34882 33.1564 8.98582" width="33.1564pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.263,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,17.503,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,20.467,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 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Journal of Oncology

fig1

Figure 1

Figure 1: CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression 