Research Article
Antitumor Effects of Paeoniflorin on Hippo Signaling Pathway in Gastric Cancer Cells
Figure 3
Overexpression of TAZ reverses the paeoniflorin-mediated cell growth inhibition. (a) Viability of MGC803 and SG7901 cells after TAZ overexpression and paeoniflorin treatment was determined by MTT assay. The results are presented as the mean ± SD. vs. control groups; vs. PF alone or cDNA transfection alone. PF: 20 μM paeoniflorin; cDNA: TAZ cDNA; both: PF exposure and TAZ cDNA transfection. (b) Apoptosis of gastric cancer cells after TAZ overexpression and paeoniflorin treatment was measured by flow cytometry. (c) Left panel: invasion of gastric cancer cells overexpressing TAZ and treated with paeoniflorin was assessed by transwell chambers assay. Right panel: quantitative results were represented for left panel.
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