Antitumor Effects of Paeoniflorin on Hippo Signaling Pathway in Gastric Cancer Cells

Figure 4

Overexpression of TAZ reverses paeoniflorin-mediated inhibition of migration and invasion. (a) Left panel: migration of gastric cancer cells overexpressing TAZ and treated with paeoniflorin was detested by wound healing assay. Right panel: quantitative results were represented for left panel. The results are presented as the mean ± SD. PF: 20 μM paeoniflorin; cDNA: TAZ cDNA; both: PF exposure and TAZ cDNA transfection. (b) The expression of TAZ and β-catenin in gastric cancer cells overexpressing TAZ and treated with paeoniflorin was measured by western blotting analysis. Right panel: quantitative results were shown for left panel.

(a)

(b)