Research Article
Antitumor Effects of Paeoniflorin on Hippo Signaling Pathway in Gastric Cancer Cells
Figure 5
Downregulation of TAZ promotes the paeoniflorin-mediated cell growth inhibition. (a) Viability of gastric cancer cells with downregulated TAZ and treated with paeoniflorin was determined by MTT assay. The results are presented as the mean ± SD. vs. control groups; vs. PF alone or siRNA transfection alone. PF: 20 μM paeoniflorin; siRNA: TAZ siRNA; both: PF exposure and TAZ siRNA transfection. (b) Apoptosis of cells with downregulated TAZ and treated with paeoniflorin was measured by flow cytometry. (c) Left panel: migration of gastric cancer cells with downregulated TAZ and treated with paeoniflorin was detested by wound healing assay. Right panel: quantitative results were represented for left panel.
(a) |
(b) |
(c) |