DAP10 Predicted the Outcome of Pediatric B-Cell Acute Lymphoblastic Leukemia and Was Associated with the T-Cell Exhaustion

Figure 5

Downregulation of DAP10 inhibited the activation of CD8+ T cells. (a) mRNA level of DAP10 in different hematopoietic cells. (b) Fluorescence intensity of DAP10 of leukemic B cells using FCM. (c) ssGSEA showed the proportions of TICs in DAP10 high and DAP10 low patients. (d) The ratio of activated CD8+ T cells decreased in DAP10 low patients. (e) The ratio of CD8+ T cells was positively correlated with DAP10. (f) GSEA analysis showed DAP10 participated in the activation of CD8+ T cells. (g) The level of IL2RG was inhibited in the DAP10 low patients. (h), (i) The level of IL2RG was positively correlated with the level of DAP10 in the patients of TARGET database and GSE13159 dataset.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)