DAP10 Predicted the Outcome of Pediatric B-Cell Acute Lymphoblastic Leukemia and Was Associated with the T-Cell Exhaustion

Figure 6

Cells that contributed to the T-cell exhaustion in the DAP10 lowly expressed patients. (a) GSEA analysis showed that patients with lower DAP10 level suffered from more severe T-cell exhaustion. (b) The ratio of central memory CD4+ T cells was downregulated in DAP10 low expression group. (c) The level of central memory CD4+ T cells was positively correlated with DAP10 expression. (d) The naive CD4+ T cells failed to activate and differentiate to type 1 CD4+ helper cells in DAP10 lowly expressed patients. (e) The ratio of activated dendritic cells was downregulated in DAP10 lowly expressed children. (f) The level of activated dendritic cells was positively correlated with DAP10 expression.

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