DAP10 Predicted the Outcome of Pediatric B-Cell Acute Lymphoblastic Leukemia and Was Associated with the T-Cell Exhaustion

Figure 7

Molecules and pathways involved in the T-cell exhaustion in the DAP10 lowly expressed patients. (a) PD1 related pathway was upregulated in the DAP10 lowly expressed patients. (b) Heatmap showed that the genes related to PD1 were enriched in DAP10 low expression patients. (c) PD1 was upregulated in DAP10 low expression group. (d) PD-L1 had no significant correlation with DAP10 level. DAP10 lowly expressed patients showed increased suppressive cytokines of TGFB (e), IFNA10 (f), and IFNA16 (g).

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