Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas

Figure 1

Chidamide or chidamide combined with radiation synergistically promotes apoptosis in NCI-H2170 and NCI-H226 cells. (a) CCK8 assay to determine the cell viability of NCI-H2170 and NCI-H226 cells with chidamide (300 nM), radiation (2 Gy), and their combinational treatment, respectively. (b-c) The proliferation rate of NCI-H2170 (b) and NCI-H226 (c) cells with chidamide (300 nM) combined with radiation treatment at single doses of 0, 1, 2, and 4 Gy. (d)–(f) Annexin V-PI double staining to determine the apoptosis rate of NCI-H2170 and NCI-H226 cells with chidamide (300 nM), radiation (2 Gy), and their combinational treatment.

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