Impacts of LOC105371267 Variants on Breast Cancer Susceptibility in Northern Chinese Han Females: A Population-Based Case-Control Study

Table 2

Basic characteristics about LOC105371267 candidate SNPs and relationship with risk of breast cancer in allele model.

SNPs	Chromosome	Position	Type	Allele (minor/major)	MAF (case/control)	HWE-^a	OR (95% CI)		FDR test	HaploReg
rs6499221	16q12.2	53036124	Intron	A/G	0.19/0.19	0.49	1.02 (0.83–1.26)	0.872	1.453	Enhancer histone marks, motifs changed
rs3931698	16q12.2	53036913	Intron	G/T	0.14/0.16	0.64	0.80 (0.64–1.02)	0.074	0.370	Enhancer histone marks, DNase, motifs changed
rs8044565	16q12.2	53040078	Intron	C/T	0.25/0.24	1.00	1.01 (0.83–1.22)	0.961	0.961	Motifs changed
rs3852740	16q12.2	53044259	Intron	G/C	0.20/0.20	0.69	0.98 (0.80–1.21)	0.874	1.093	Promoter histone marks, enhancer histone marks, DNase, proteins bound, motifs changed
rs111577197	16q12.2	53049243	Intron	T/C	0.22/0.21	0.80	1.09 (0.89–1.33)	0.433	1.083	Enhancer histone marks, motifs changed

SNP: single-nucleotide polymorphism; MAF: minor allele frequency; HWE: Hardy–Weinberg equilibrium; OR: odds ratio; 95% CI: 95% confidence interval. Note: OR and 95% CI were computed by logistic regression analysis with adjustments for age. ^a values for the Hardy–Weinberger equilibrium (HWE) test, calculated by Fisher’s exact test. ^b values were calculated by two-sided χ2 test after adjustment for age with logistic regression analysis.