Impacts of LOC105371267 Variants on Breast Cancer Susceptibility in Northern Chinese Han Females: A Population-Based Case-Control Study
Table 3
FPRP evaluation for association between LOC105371267 variants and breast cancer risk.
Group (subgroup)/variants/genotype
OR (95% CI)
Powera, OR = 2
OR = 2
Prior probability level
0.25
0.1
0.01
0.001
0.0001
Overall/rs3931698/GT vs. TT
0.30 (0.11–0.82)
0.160
0.284
0.544
0.929
0.993
0.999
Overall/rs3931698/GG vs. GT + TT
0.30 (0.11–0.84)
0.165
0.262
0.516
0.922
0.992
0.999
Age <52 years/rs3931698/GG vs. TT
0.26 (0.17–0.97)
0.165
0.449
0.71
0.964
0.996
0.999
Age <52 years/rs3931698/additive
0.68 (0.48–0.95)
0.964
0.069
0.182
0.709
0.961
0.996
Age <52 years/rs6499221/AG vs. GG
1.48 (1.01–2.19)
0.934
0.138
0.325
0.841
0.982
0.998
PR status/rs3931698/GT vs. TT
1.52 (1.01–2.29)
0.905
0.13
0.31
0.832
0.98
0.998
PR status/rs3931698/GG +GT vs. TT
1.50 (1.01–2.25)
0.918
0.141
0.329
0.844
0.982
0.998
TNM stage/rs3931698/GT vs. TT
1.58 (1.04–2.40)
0.865
0.1
0.25
0.785
0.974
0.997
ER status/rs6499221/additive
1.43 (1.02–2.02)
0.972
0.116
0.282
0.812
0.978
0.998
ER status/rs3852740/additive
0.73 (0.53–0.99)
0.993
0.115
0.28
0.811
0.977
0.998
OR: odd ratio; 95% CI: 95% confidence interval; ER: estrogen receptor; RP: progesterone receptor. Note: OR and 95% CI were computed by logistic regression analysis with adjustments for age. a statistical power to detect an OR of 2; FPRP value < 0.2 in bold.
