UCA1 Overexpression Promotes Hypoxic Breast Cancer Cell Proliferation and Inhibits Apoptosis via HIF-1α Activation

Figure 2

(a) Significant upregulation of UCA1 lncRNA in MCF-7 cells with DMOG treatment suggests UCA1 is regulated by HIF. (b) Effective HIF-1α and HIF-2α knockdown in hypoxic MCF-7 cells using HIF-1α and HIF-2α siRNA, respectively. (c) Significant downregulation of UCA1 lncRNA upon HIF-1a siRNA in hypoxic MCF-7 cells, suggesting that UCA1 expression is HIF-1a-dependent in hypoxia. HIF-2a siRNA did not affect expression of UCA1. ; .

(a)

(b)

(c)