LSD1 as a Biomarker and the Outcome of Its Inhibitors in the Clinical Trial: The Therapy Opportunity in Tumor

Figure 2

Substrate detailed and directive of gene expression by LSD1. For targeted gene expression inhibition, the removal of H3 from H3K4me1/2 was attained by binding LSD1 to CoREST and NuRD complex. The binding of LSD1 to the CoREST and NuRD complex did not speed up the removal of H3 from H3K9me1/2. For targeted gene expression control, the modification of substrate specificity from H3K4me1/2 to H3K9me1/2 was attained by LSD1 binding to androgen and estrogen receptors.