The Potential of circRNA as a Novel Diagnostic Biomarker in Cervical Cancer

Table 1

circRNA expression associated with cervical cancer.

circRNA	Unusual expression	Target genes	Functions	Clinical relevance	Ref.
circRNA_101996	Up	miR-8075	Proliferation, invasion, and migration	TNM stage, tumor size, and lymph node metastasis	[10]
circRNA_0000263	Up	miR-150-5p	Proliferation and migration	Tumor size and lymph node metastasis	[11]
circRNA_0000745	Up	E-cadherin	Proliferation, invasion, and migration	Tumor differentiation and lymphatic invasion	[8]
circRNA_0007534	Up	miR-498	Proliferation and invasion	Tumor size	[9]
circRNA_0031288	Up	hsa-miR-139-3p	Invasion and migration	Lymph node metastasis and infiltration	[12]
circRNA_SLC26A4	Up	miR-1287-5p	Proliferation and invasion	Tumor size	[13]
circRNA_AKT1	Up	miR-942-5p	Proliferation and invasion	Tumor size	[14]
circRNA_CLK3	Up	miR-320a	Proliferation, invasion, and migration	Tumor differentiation, FIGO staging, and stromal infiltration	[15]
circRNA_8924	Up	miR-518d-5p	Proliferation, invasion, and migration	Tumor size, FIGO staging, and muscle invasion	[16]
circRNA__0000285	Up	miR197-3p-ELK1	Cycle and apoptosis	Tumor size	[17]
circRNA_EIF4G2	Up	miR-218	Proliferation, invasion, and migration	Tumor size and lymph node metastasis	[18]
circRNA__0084927	Up	miR-142-3p	Proliferation, invasion, migration, and cycle	Tumor size	[19]
circRNA__FoxO3a	Up	—	Infiltration and migration	Stroma infiltration and lymph node metastasis	[20]
circRNA_101308	Up	miR-26a-5p	Proliferation, invasion, and migration	Lymph node metastasis and deep muscle layer infiltration	[21]