CD8⁺ T Lymphocyte Coexpression Genes Correlate with Immune Microenvironment and Overall Survival in Breast Cancer

Figure 2

(a) We evaluated 860 breast cancer samples accurately using CD8+ T lymphocytes. (b) Hierarchical clustering tree was built using the dynamic hybrid cutting method. (c) Twenty-two coexpression models were identified. The yellow module had the strongest correlation with CD8+ T lymphocyte proportion in the TCGA-BRCA cohort (Cor = -0.41;  = 1e − 28). (d) The yellow module showed a significant correlation to CD8+ T Cell (Cor = 0.78,  = 9.7e − 259), (e) tumor purity (Cor = 0.86,  = 1.7e − 83), (f) immune score (Cor = 0.98,  = 1.2e − 197), and (g) stomal score (Cor = 0.28,  = 1.9e − 06).

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