Plasma-Derived Exosomal microRNA-130a Serves as a Noninvasive Biomarker for Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Table 3

Clinicopathological characteristics of patients with OSCC.

Clinicopathological factors	No.	Exosomal miR-130a expression
		Low, N (%)	High, N (%)	value
Age
< 60 years	82	43 (23.4)	39 (21.2)	0.553
≥ 60 years	102	49 (26.6)	53 (28.8)
Gender
Male	125	59 (32.1)	66 (35.9)	0.269
Female	59	33 (17.9)	26 (14.1)
Smoking habit
Yes	102	50 (27.2)	52 (28.3)	0.767
No	82	42 (22.8)	40 (21.7)
Drinking habit
Yes	134	65 (35.3)	69 (37.5)	0.507
No	50	27 (14.7)	23 (12.5)
Tumor site
Tongue	83	43 (23.4)	40 (21.7)	0.657
Nontongue	101	49 (26.6)	52 (28.3)
T-stage
T1 + T2	111	63 (34.2)	48 (26.1)	0.024
T3 + T4	73	29 (15.8)	44 (23.9)
N-stage
Negative	115	63 (34.2)	52 (28.3)	0.094
Positive	69	29 (15.8)	40 (21.7)
TNM stage
I-II	104	62 (33.7)	42 (22.8)	0.003
III-IV	80	30 (16.3)	50 (27.2)
Histologic grade
Well + moderate	120	68 (37)	52 (28.3)	0.013
Poor	64	24 (13)	40 (21.7)

Mean value<0.05.