Plasma-Derived Exosomal microRNA-130a Serves as a Noninvasive Biomarker for Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Table 4

Univariate and multivariate analyses of overall survival in 184 patients with OSCC.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Exosomal miR-130a (high)	4.412 (2.265–8.591)	<0.001	3.276 (1.624–6.607)	0.001
Age (≥60 years)	1.007 (0.546–1.859)	0.981
Gender (male)	1.358 (0.713–2.585)	0.352
Smoking habit (yes)	1.206 (0.654–2.224)	0.548
Drinking habit (yes)	1.482 (0.728–3.016)	0.277
Tumor site (tongue)	1.039 (0.555–1.948)	0.904
T-stage (T3 + T4)	2.227 (1.195–4.153)	0.012	1.853 (0.933–3.682)	0.078
N-stage (positive)	1.546 (0.831–2.877)	0.169
TNM stage (III-IV)	2.581 (1.382–4.821)	0.003	2.07 (1.046–4.097)	0.037
Histologic grade (poor)	2.871 (1.517–5.434)	0.001	2.199 (1.102–4.389)	0.025

HR: hazard ratio; CI: confidence interval; mean value<0.05.