Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics

Figure 1

Proteomic profiles of normal mucosa, adenoma, and carcinoma tissues. (a) Venn diagram showing the intersection of the available proteins identified in the three duplicates. (b) Hierarchical clustering analysis of the grouped proteomic profiles of normal mucosa, adenoma, and carcinoma tissues in each replicate. C1: proteomic profiles of carcinoma in R1; C2: proteomic profiles of carcinoma in R2, and so forth. (c) Volcano plot of the DEPs between CG and NG. (d) Volcano plot of the DEPs between AG and NG. (e) Volcano plot of the DEPs between CG and AG. DEPs: differentially expressed proteins; CG: carcinoma group; AG: adenoma group; NG: normal group. NS: no statistically significant differences; Down: downregulated proteins; Up: upregulated proteins.

(a)

(b)

(c)

(d)

(e)