Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics

Figure 4

Immunohistochemical analysis to validate the discrimination power in the N-A-C sequence. (a) Representative images of RRP12 and SERPINH1 IHC staining in normal, adenoma, and carcinoma tissues. (b) In 40 paired normal, adenoma, and cancer tissues, the RRP12 expression level increased significantly in the N-A-C sequence. (c) In ROC analysis, the AUC values of RRP12 in the N-A and N-C processes were 0.760 and 0.909, respectively. (d) In 40 paired normal, adenoma, and cancer tissues, the SERPINH1 expression level increased significantly in the N-A-C sequence. (e) In ROC analysis, the AUCs of SERPINH1 in the A-C and N-C processes were 0.800 and 0.969, respectively.

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