Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics

Figure 6

SERPINH1 is a risk factor for DFS and correlates with increased TNM stage and EMT phenotype. (a) The DFS of the high SERPINH1 expression group is significantly poorer than that of the low expression group in our database (, 59 patients). (b) There is no significant difference in the DFS of the high RRP12 expression group (IHC score ≥9 points) compared with the low expression group in our database (IHC score <9 points) (, 59 patients). (c) The DFS of the high SERPINH1 expression group is significantly poorer than that of the low expression group in the TCGA database (, 372 patients). (d) There is no significant difference in the DFS of the high RRP12 expression group compared with the low expression group in the TCGA database in DFS (, 372 patients). (e) In the CPTAC database, the expression level of SERPINH1 is significantly higher in the stage I–IV groups compared with the normal group. Furthermore, the SERPINH1 expression level is higher in the stage III and stage IV groups compared with that in the stage I group (data obtained from UALCAN). (f) In the CPTAC database, the RRP12 expression level is significantly higher in the stage I–IV groups compared with that in the normal group (data obtained from UALCAN). (g) In the CPTAC database, the SERPINH1 expression level in the EMT group is significantly higher than that in the epithelial group (data obtained from cBioPortal). (h) In the CPTAC database, the RRP12 expression level in the EMT group is significantly lower than that in the epithelial group (data obtained from cBioPortal).

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