POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3-AS1

<div>POU2F1 directly binds to the promoter region of TTC3-AS1. (a) The predicted POU2F1 binding sequences on the upstream of TTC3-AS1 promoter region. (b) ChIP and (c) DAPA assays were performed to reveal the affinity of POU2F1 to the TTC3-AS1 promoter in SGC7901 cells. (d) Luciferase reporter assay: luciferase reporter vectors TTC3-AS1-wild type (WT) and TTC3-AS1-mutant type (MT) including TTC3-AS1-MT1 (786–797 bp) and TTC3-AS1-MT2 (1,066–1,077 bp) were constructed. These luciferase reporter vectors were transfected into SGC901 cells together with the POU2F1 overexpression vector. 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Journal of Oncology

fig1

Figure 1

Figure 1: POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3-AS1 