POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3-AS1

<div>POU2F1 promoted GC cell viability, invasion, and migration of GC cells and promoted the expression of TTC3-AS1. (a) POU2F1 was, respectively, overexpressed by plasmid transfection and knocked down by siRNA transfection in SGC7901 cells; SGC7901 cells were divided into three groups, NC, POU2F1-KD, and POU2F1-OE, and function experiments were performed. (b) Cell viability was detected using CCK-8 assays, and cell migration and invasion were, respectively, detected using (c) scratch assay and (d) transwell assay. (e) Protein expression of POU2F1, E-cad, and FN1 was detected using western blot. (f) The effects of POU2F1 knockdown or overexpression on TTC3-AS1 expression were evaluated by using qRT-PCR. All experiments were performed in triplicate. 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Journal of Oncology

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Figure 6

Figure 6: POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3-AS1 