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| Biological process terms | FDR | Top 50 genes |
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| Upregulated genes |
| Anatomical structure morphogenesis | 1.75E − 29 | GAS7 ADGRA2 PITX1 MAP4K4 WDR1 FRYL ISM1 HOXA2 PMP22 CDH6 COL7A1 PLXNA1 RHOQ BHLHE41 RHOJ PALLD MAP1S PLXNA3 RAMP2 ZSWIM4 BHLHE40 RAC1 TMOD1 SULF1 THBS1 PARVG RNF165 COL6A1 COL6A2 SLIT2 VEGFC THY1 PGM5 BRSK1 LRP5 COL6A3 LMOD1 HEYL NIPBL DACT1 ILK MAP1A ISLR2 LUZP1 SEMA3E |
| Regulation of the cellular component organization | 5.22E − 23 | APP UBE2J2 ARIH2 WDR1 OGFOD1 PALM VPS18 ARHGEF10 TESK1 PLXNA1 ALMS1 PLEKHM2 CCND2 RHOQ RHOJ MACF1 MAP1S PLXNA3 ZSWIM4 ARHGAP17 RHOT2 SLIT2 ASAP1 THY1 WHAMM DDR2 NIPBL NDEL1 MAP1A ISLR2 RAB4B SEMA3E CLSTN1 RHOG CDC42EP4 H1FX ATXN2 ZSWIM8 STON1 TWF2 APOPT1 NOL12 SYT11 |
| Regulation of the developmental process | 2.52E − 21 | APP ISM1 PLXNA1 RHOQ BHLHE41 CNOT1 RHOJ JUND PLXNA3 ZSWIM4 BHLHE40 SULF1 THBS1 VEGFC THY1 HEYL DACT1 NDEL1 RBPMS2 ISLR2 SEMA3E JUNB CLSTN1 RHOG APOLD1 CDC42EP4 MAFF THBS2 HES4 MAFG ENPP1 ZSWIM8 TWF2 NFKB1 HSPB6 PTBP1 DCN RNH1 FOXJ2 VASH1 NUAK1 FBLN1 YPEL3 SETD1A SYNDIG1 |
| Actin filament-based process | 3.95E − 18 | GAS7 WDR1 FSCN1 SPECC1L ARHGEF10 TESK1 EPB41L5 RHOQ RHOJ LLGL1 RAC1 TMOD1 PARVG FRMD6 TPM1 ARHGAP17 IQSEC1 PGM5 WHAMM SHROOM4 LMOD1 TPM4 RHOG CDC42EP4 SMTN TPM2 AIF1 TWF2 CNN2 PPM1F MYH9 HCK CORO1A ARHGEF18 TGFB3 MYH10 MICAL1 SLIT2 DLC1 DAPK3 TYROBP MEF2A ACTN1 |
| Cell adhesion | 3.53E − 17 | MYH9 MYL9 TLN1 CSRP1 ILK ITGB5 ICAM2 CDH6 PLXNA1 TGFBI MACF1 PALLD PLXNA3 EMILIN1 PARVG FER THY1 ITGB2 DDR2 FBLN2 CERCAM NLGN2 CDH5 TENM3 ZYX NUAK1 FBLN1 SPECC1L SERPINE1 VWF BVES DUSP22 THBS4 ADAM19 HAVCR2 RAC1 THBS1 ERBB2 MSN NOTCH1 SPOCK1 ITGA5 PDPN IGFBP7 DLC1 DAPK3 |
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| Downregulated genes |
| RNA processing | 7.24E − 27 | NSUN2 TRIT1 THUMPD1 FTSJ1 RBM7 MBNL3 SEPHS1 PAPOLA GEMIN2 SRPK1 PES1 PHF5A DICER1 PRPF6 RIOK3 RBM3 ERI1 POP4 EXOSC3 DHX40 INTS2 FTSJ3 UTP6 LUC7L3 PUS3 NOP2 SRSF3 BYSL DROSHA NCBP2 SF3B6 SFPQ RPF1 PRPF3 PPP1R8 CPSF3 HEATR1 RBM25 EXOSC8 TRMT1L HNRNPA2B1 EXOSC9 RRP36 SNRPC AARS2 RIOK1 RNF113A TRMT5 NGDN |
| Organonitrogen compound biosynthetic process | 1.40E − 24 | MRPS17 DPM1 GCLC ELOVL5 COX15 SARS FUT8 ADSS CTPS2 GATB PIGV ZC3H15 ELOVL1 IARS2 COASY FTSJ1 ASNS RPL31 HACD3 ITM2A POMGNT1 SEPHS1 RPL6 RPLP0 EIF3L RBM23 PIGH PIGU PRPS2 PGK1 SMS RBM3 HAS3 GSPT1 ZDHHC2 GARS C1GALT1 EIF3A PNPO UGDH GAPDH TPI1 HDDC2 MTRF1L MRPL2 TARS RARS SPR CTH WARS2 RPN2 ALG5 ETF1 SERP1 MTIF3 |
| Mitotic cell cycle | 9.63E − 24 | PAFAH1B1 ANLN PHF23 TUBE1 NDC80 PDS5B ZW10 PEBP1 BIRC5 KIF4A MSH2 RANBP1 PSME2 POLA1 NBN CCNJ BCCIP TUBD1 DUSP3 UNC119 NCAPG ANAPC15 CDKN1B CCNG1 NEK11 MSH6 NEK2 NSL1 NAA50 KIF18A CDK2 CKS2 MSTO1 STK33 CCNB1 USP26 DSCC1 TUBB2A NUSAP1 KIF23 KIF11 CEP55 CCNG2 CENPE CLTC ANAPC11 NUF2 CENPC DSN1 TUBA3E |
| Organelle organization | 1.09E − 22 | TUBB2A NUSAP1 KIF23 RSL24D1 KIF11 MNS1 USP8 NUP54 CCNG2 CENPE UQCRC2 AFG3L2 ESCO1 ANAPC11 PLK4 MTF2 NUF2 GOLPH3L RHOB EML4 LNPK HSPD1 DYNC1LI1 CENPC ABT1 PHIP ARHGAP18 ADD3 DSN1 TWF1 TUBA3E PSTPIP2 HAUS1 TADA1 CCNO SAR1B ANAPC1 INO80C TRIP12 BUB3 EME1 NDUFAF6 WHAMM PCGF6 UQCRB MTERF3 BUB1B TMED6 |
| Cellular response to stress | 4.35E − 21 | RECQL SPAG9 SPRTN MAP4K3 BRCA1 ERCC1 MBTPS2 MAP4K5 HSF2 BAK1 MAP2K3 GABARAPL2 ERCC8 RAD51 PMS1 SLK POLB MLH1 UNG TRAF4 UBE2T XRCC5 HSP90AA1 PDS5B MSH2 MAP3K1 CDC7 PSMC6 POLA1 NBN UBR5 GSR RPA3 ERLIN1 NSMCE4A BCCIP MAP3K8 DUSP3 MAP2K6 HSPA8 UBE4A TDP2 ASCC3 HSPA9 OGG1 NEK11 AUP1 NFE2L2 MSH6 PRDX1 |
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