Transcriptional and Epigenetic Bioinformatic Analysis of Claudin-9 Regulation in Gastric Cancer

Figure 4

Methylation of CLDN9, CLDN6, and CDH1 genes. Methylation level of (a) CLDN9, (b) CLDN6, and (c) CDH1 under gastric cancer condition compared with normal tissue. (d) Heatmap of the methylation of CLDN9, CLDN6, and CDH1 genes. (e) Overall Survival probability between CLDN9 high-methylation level (≥0.5050 average) vs. low-methylation level (<0.5050 average), , Log-Rank = 0.162. (f) Disease-free interval between CLDN9 high-methylation level (≥0.5050 average) vs. low-methylation level (<0.5050 average), , Log-Rank = 0.125. (g) Progression-free interval between CLDN9 high-methylation level (≥0.5050 average) vs. low-methylation level (<0.5050 average), , Log-Rank = 0.892.

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