Association of HER1 and HER2 Gene Variants in the Predisposition of Colorectal Cancer

Table 3

HER1 and HER2 SNPs' genotype and allele frequencies in colorectal cancer cases and the control population based on age.

SNP ID	Genotype	Controls n (frequency)	Colorectal cancer n (frequency)	OR (95% CI)	χ^2 value	p^∗ value
≤58
rs763317 HER1	AA	22 (0.29)	16 (0.23)	Ref
	GA	46 (0.6)	41 (0.58)	1.226 (0.568-2.645)	0.27	0.60413
	GG	9 (0.12)	14 (0.2)	2.139 (0.744-6.151)	2.02	0.15540
	Allele
	A	90 (0.58)	73 (0.51)	Ref
	G	64 (0.42)	69 (0.49)	1.329 (0.840-2.104)	1.48	0.22426
rs3752651 HER1	TT	60 (0.71)	53 (0.74)	Ref
	CT	20 (0.24)	19 (0.26)	1.075 (0.519-2.228)	0.04	0.84480
	CC	4 (0.05)	0 (0)	0.126 (0.007-2.388)	3.43	0.06403
	Allele
	T	140 (0.83)	125 (0.87)	Ref
	C	28 (0.17)	19 (0.13)	0.760 (0.405-1.428)	0.73	0.39268
rs1058808 HER2	GG	30 (0.36)	22 (0.31)	Ref
	CG	44 (0.53)	32 (0.46)	0.992 (0.486-2.026)	0.00	0.98183
	CC	9 (0.11)	16 (0.23)	2.424 (0.906-6.490)	3.18	0.07462
	Allele
	G	104 (0.63)	76 (0.54)	Ref
	C	62 (0.37)	64 (0.46)	1.413 (0.894-2.232)	2.19	0.13855
rs1136201 HER2	AA	65 (0.78)	62 (0.87)	Ref
	AG	17 (0.2)	9 (0.13)	0.555 (0.230-1.338)	1.75	0.18580
	GG	1 (0.01)	0 (0)	0.349 (0.014-8.737)	0.95	0.33054
	Allele
	A	147 (0.89)	133 (0.94)	Ref
	G	19 (0.11)	9 (0.06)	0.524 (0.229-1.197)	2.42	0.12010
>58
rs763317 HER1	AA	21 (0.29)	24 (0.35)	Ref
	GA	36 (0.5)	32 (0.46)	0.778 (0.366-1.654)	0.43	0.51372
	GG	15 (0.21)	13 (0.19)	0.758 (0.295-1.953)	0.33	0.56612
	Allele
	A	78 (0.54)	80 (0.58)	Ref
	G	66 (0.46)	58 (0.42)	0.857 (0.535-1.372)	0.41	0.51996
rs3752651 HER1	TT	59 (0.75)	49 (0.69)	Ref
	CT	18 (0.23)	22 (0.31)	1.472 (0.710-3.051)	1.08	0.29770
	CC	2 (0.03)	0 (0)	0.240 (0.011-5.126)	1.64	0.20083
	Allele
	T	136 (0.86)	120 (0.85)	Ref
	C	22 (0.14)	22 (0.15)	1.133 (0.598–2.149)	0.15	0.70134
rs1058808 HER2	GG	32 (0.42)	22 (0.32)	Ref
	CG	37 (0.48)	39 (0.57)	1.533 (0.758–3.103)	1.42	0.23381
	CC	8 (0.1)	8 (0.12)	1.455 (0.474–4.459)	0.43	0.51096
	Allele
	G	101 (0.66)	83 (0.6)	Ref
	C	53 (0.34)	55 (0.4)	1.263 (0.784–2.033)	0.92	0.33644
rs1136201 HER2	AA	58 (0.73)	58 (0.83)	Ref
	AG	20 (0.25)	12 (0.17)	0.600 (0.269–1.339)	1.57	0.20989
	GG	1 (0.01)	0 (0)	0.333 (0.013–8.352)	0.99	0.31937
	Allele
	A	136 (0.88)	128 (0.91)	Ref
	G	22 (0.14)	12 (0.09)	0.580 (0.276–1.219)	2.10	0.14691

OR 95% CI, odds ratio and 95% confidence interval. was considered significant and are depicted in bold.