Research Article
Association of HER1 and HER2 Gene Variants in the Predisposition of Colorectal Cancer
Table 4
HER1 and HER2 SNPs’ genotype and allele frequencies in colorectal cancer cases and the control population based on gender.
| | SNP ID | Genotype | Controls, n (frequency) | Colorectal cancer, n (frequency) | OR (95% CI) | χ2 value | value |
| | Male | | rs763317 HER1 | AA | 24 (0.33) | 21 (0.25) | Ref | | | | GA | 38 (0.52) | 45 (0.54) | 1.353 (0.654–2.802) | 0.67 | 0.41445 | | GG | 11 (0.15) | 18 (0.21) | 1.870 (0.722–4.844) | 1.68 | 0.19514 | | Allele | | | | | | | A | 86 (0.59) | 87 (0.52) | Ref | | | | G | 60 (0.41) | 81 (0.48) | 1.334 (0.853–2.088) | 1.60 | 0.20592 |
| | rs3752651 HER1 | TT | 51 (0.63) | 60 (0.71) | Ref | | | | CT | 25 (0.31) | 25 (0.29) | 0.850 (0.436–1.658) | 0.23 | 0.63351 | | CC | 5 (0.06) | 0 (0) | 0.077 (0.004–1.433) | 5.60 | 0.01798 | | Allele | | | | | | | T | 127 (0.78) | 145 (0.85) | Ref | | | | C | 35 (0.22) | 25 (0.15) | 0.626 (0.355–1.102) | 2.67 | 0.10247 |
| | rs1058808 HER2 | GG | 31 (0.38) | 28 (0.33) | Ref | | | | CG | 39 (0.48) | 44 (0.52) | 1.249 (0.640–2.437) | 0.43 | 0.51412 | | CC | 11 (0.14) | 12 (0.14) | 1.208 (0.460–3.169) | 0.15 | 0.70110 | | Allele | | | | | | | G | 101 (0.62) | 100 (0.6) | Ref | | | | C | 61 (0.38) | 68 (0.4) | 1.126 (0.723–1.753) | 0.28 | 0.59945 |
| | rs1136201 HER2 | AA | 61 (0.75) | 67 (0.8) | Ref | | | | AG | 20 (0.25) | 17 (0.2) | 0.774 (0.372–1.612) | 0.47 | 0.49294 | | GG | 0 (0) | 0 (0) | 0.911 (0.018–46.620) | Na | 1.00000 | | Allele | | | | | | | A | 142 (0.88) | 151 (0.9) | Ref | | | | G | 20 (0.12) | 17 (0.1) | 0.799 (0.403–1.587) | 0.41 | 0.52159 |
| | Female | | rs763317 HER1 | AA | 19 (0.25) | 19 (0.34) | Ref | | | | GA | 44 (0.58) | 28 (0.5) | 0.636 (0.288–1.406) | 1.25 | 0.26263 | | GG | 13 (0.17) | 9 (0.16) | 0.692 (0.240–2.001) | 0.46 | 0.49638 | | Allele | | | | | | | A | 82 (0.54) | 66 (0.59) | Ref | | | | G | 70 (0.46) | 46 (0.41) | 0.816 (0.498–1.337) | 0.65 | 0.42027 |
| | rs3752651 HER1 | TT | 68 (0.83) | 42 (0.72) | Ref | | | | CT | 13 (0.16) | 16 (0.28) | 1.993 (0.872–4.555) | 2.72 | 0.09881 | | CC | 1 (0.01) | 0 (0) | 0.537 (0.021–13.492) | 0.61 | 0.43320 | | Allele | | | | | | | T | 149 (0.91) | 100 (0.86) | Ref | | | | C | 15 (0.09) | 16 (0.14) | 1.589 (0.752–3.360) | 1.49 | 0.22221 |
| | rs1058808 HER2 | GG | 31 (0.39) | 16 (0.29) | Ref | | | | CG | 42 (0.53) | 27 (0.49) | 1.246 (0.575–2.699) | 0.31 | 0.57754 | | CC | 6 (0.08) | 12 (0.22) | 3.875 (1.226–12.248) | 5.65 | 0.01746 | | Allele | | | | | | | G | 104 (0.66) | 59 (0.54) | Ref | | | | C | 54 (0.34) | 51 (0.46) | 1.665 (1.011–2.741) | 4.04 | 0.04439 |
| | rs1136201 HER2 | AA | 62 (0.77) | 53 (0.93) | Ref | | | | AG | 17 (0.21) | 4 (0.07) | 0.275 (0.087–0.869) | 5.33 | 0.02093 | | GG | 2 (0.02) | 0 (0) | 0.234 (0.011–4.974) | 1.69 | 0.19425 | | Allele | | | | | | | A | 141 (0.89) | 110 (0.96) | Ref | | | | G | 21 (0.13) | 4 (0.04) | 0.244 (0.081–0.732) | 7.26 | 0.00705 |
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OR 95% CI, odds ratio and 95% confidence interval; na, not analyzable. was considered significant and are depicted in bold. |
