Effect of the Number of Removed Lymph Nodes on Survival in Patients with FIGO Stage IB-IIA Cervical Squamous Cell Carcinoma following Open Radical Hysterectomy with Pelvic Lymphadenectomy: A Retrospective Cohort Study
Table 3
Cox proportional hazard analysis on prognostic factors related to survival in LN positive patients.
Variable
PFS
OS
Univariate
Multivariate 1
Multivariate 2
Univariate
Multivariate 1
Multivariate 2
value
HR
95% CI
value
HR
95% CI
value
value
HR
95% CI
value
HR
95% CI
value
Age, years
0.713
0.507
Menopausal status
0.989
0.643
FIGO stage
0.005
1.260
0.870–1.823
0.221
1.254
0.866–1.815
0.230
0.331
Tumor diameter (cm)
0.005
1.468
1.052–2.049
0.024
1.464
1.049–2.042
0.025
0.007
1.664
1.057–2.620
0.028
1.712
1.090–2.691
0.020
Depth of stromal invasion
0.002
2.695
1.167–6.222
0.02
2.719
1.176–6.285
0.019
0.046
2.224
0.690–7.164
0.181
2.127
0.659–6.863
0.207
LVSI
0.014
1.610
1.024–2.531
0.039
1.602
1.020–2.516
0.041
0.007
2.458
1.216–4.966
0.012
2.495
1.235–5.042
0.011
Parametrial invasion
<0.001
2.043
1.393–2.998
<0.001
2.033
1.387–2.979
<0.001
0.001
1.721
1.013–2.924
0.045
1.779
1.049–3.016
0.032
Vaginal margin invasion
0.009
1.914
1.104–3.318
0.021
1.914
1.104–3.319
0.021
0.389
No. of RLN
0.542
0.969
0.699–1.345
0.853
0.176
1.264
0.717–2.229
0.419
No. of RLN (continuous)
0.625
1.001
0.981–1.021
0.938
0.763
0.989
0.959–1.019
0.458
FIGO, Federation of Gynecology and Obstetrics; LVSI, lymph-vascular space invasion; RLN, removed lymph nodes.
