Effect of the Number of Removed Lymph Nodes on Survival in Patients with FIGO Stage IB-IIA Cervical Squamous Cell Carcinoma following Open Radical Hysterectomy with Pelvic Lymphadenectomy: A Retrospective Cohort Study
Table 4
Cox proportional hazard analysis on prognostic factors related to survival in LN negative patients.
Variable
PFS
OS
Univariate
Multivariate 1
Multivariate 2
Univariate
Multivariate 1
Multivariate 2
value
HR
95% CI
value
HR
95% CI
value
value
HR
95% CI
value
HR
95% CI
value
Age, years
0.001
0.700
0.391–1.253
0.230
0.689
0.384–1.235
0.211
0.035
0.416
0.188–0.920
0.030
0.411
0.185–0.909
0.028
Menopausal status
<0.001
1.836
1.033–3.262
0.038
1.865
1.048–3.320
0.034
0.001
2.683
1.229–5.854
0.013
2.718
1.247–5.922
0.012
FIGO stage
<0.001
1.702
1.211–2.392
0.002
1.704
1.212–2.395
0.002
<0.001
1.917
1.171–3.137
0.010
1.929
1.178–3.160
0.009
Tumor diameter (cm)
0.074
0.001
1.887
1.183–3.010
0.008
1.873
1.174–2.990
0.008
Depth of stromal invasion
<0.001
1.799
1.175–2.753
0.007
1.799
1.175–2.755
0.007
<0.001
4.276
1.925–9.498
<0.001
4.294
1.932–9.543
<0.001
LVSI
<0.001
2.186
1.571–3.041
<0.001
2.180
1.567–3.033
<0.001
<0.001
2.433
1.535–3.855
<0.001
2.431
1.534–3.853
<0.001
Parametrial invasion
0.046
1.309
0.633–2.707
0.467
1.307
0.632–2.702
0.470
0.003
1.860
0.793–4.359
0.154
1.791
0.766–4.187
0.178
Vaginal margin invasion
<0.001
2.085
1.177–3.694
0.012
2.095
1.182–3.713
0.011
<0.001
3.635
1.801–7.337
<0.001
3.618
1.795–7.294
<0.001
Adjuvant therapy
0.016
0.688
0.466–1.016
0.060
0.687
0.465–1.015
0.059
0.003
0.582
0.333–1.017
0.057
0.581
0.332–1.017
0.057
No. of RLN
0.213
1.220
0.901–1.652
0.199
0.498
1.272
0.733–2.207
0.393
No. of RLN (continuous)
0.353
1.011
0.991–1.031
0.267
0.211
1.016
0.986–1.047
0.295
FIGO, Federation of Gynecology and Obstetrics; LVSI, lymph-vascular space invasion; RLN, removed lymph nodes.
