Identification of a Pyroptosis-Related Gene Signature for Prediction of Overall Survival in Lung Adenocarcinoma

Figure 1

Genes associated with pyroptosis in LUAD have distinct characteristics and differences. (a) Heatmap depicting the variations in pyroptosis-related gene expression between the normal and tumor samples. (b) A network of correlations including pyroptosis-related genes in the TCGA cohort. (c) The mutation landscape in 561 LUAD patients from the TCGA-LUAD cohort. Each pyroptosis-related gene’s mutation information was displayed by a waterfall plot. Annotations at the bottom of the corresponding hues denoted various mutation types. The barplot above depicted the mutation load. Individual mutation frequencies were indicated by the right values. (d) The TCGA cohort’s location of CNV modification of genes associated with pyroptosis on chromosomes. (e) Pyroptosis-related gene CNV frequency in the TCGA cohort. The height of the columns revealed various proportions. Copy number variants, or CNVs, are a kind of copy number variation.

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