The Role of miR-23b in Cancer and Autoimmune Disease

Figure 1

The mechanism of miR-23b in cancers. (1) Breast cancer: HER2, EGF, and TNF-α promote the growth of BT474 cells by promoting the upregulation of miR-23b. Cas/ErbB2 MCF10A.B2 represents overexpression p130Cas with activation of ErbB2. miR-23b impairs Cas/ErbB2 MCF10A.B2 cell invasion by downmodulating Blimp1 expression. (2) Lung cancer: miR-23b promotes H1838, H1437, and H1944 lung cancer cell proliferation. It is beneficial for the growth of A549 by Mcl-1S. In addition, KTN1-AS1 promotes NSCLC proliferation by inhibiting miR-23b. (3) Liver cancer: miR-23b boosts the proliferation of H1838, H1437, and H1944 lung cancer cell lines. It is useful for the expansion of A549 by Mcl-1S. Furthermore, KTN1-AS1 accelerates NSCLC proliferation by inhibiting miR-23b. (4) Gastric cancer: miR-23b modulates tumor growth by targeting PDCD4. Moreover, as a potential target of miR-23b, TUSC7 also regulates the growth of gastric cancer cells AGS and MKN-45.