The Role of miR-23b in Cancer and Autoimmune Disease

Figure 2

The mechanism of miR-23b in MS, RA, and SLE. IKK-α could promote the expression of inflammatory factor NF-ᶄB, which contributes to the occurrence of autoimmune diseases RA, SLE, and MS/EAE. Additionally, miR-23b could alleviate these diseases by inhibiting TAB2 and TAB3, which are beneficial for IKK-α. Besides, the binding of miR-23b to CCL7 can inhibit the migration of inflammatory cells Th1 and Th17 and ultimately inhibit disease development.