Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis

Table 3

Soluble factors showing decreased levels in melanoma patients vs. healthy controls.

Cytokine	Median (range), pg/ml	Significance
BDNF
Healthy donors	769.86 (320.02∼1161.64)
Primary melanoma	332.13 (4.70∼943.70)
Metastatic melanoma	230.67 (14.62∼774.21)
SDF-1α
Healthy donors	600.59 (398.09∼857.74)
Primary melanoma	384.47 (197.16∼825.62)
Metastatic melanoma	423.54 (205.60∼601.79)
MCP-1
Healthy donors	183.05 (54.91∼358.44)
Primary melanoma	102.12 (21.67∼315.81)
Metastatic melanoma	128.53 (26.65∼228.36)
Eotaxin
Healthy donors	76.733 (13.76∼144.17)
Primary melanoma	43.98 (5.8∼114.72)
Metastatic melanoma	39.98 (5.62∼124.05)
EGF
Healthy donor	72.34 (2.91∼123.27)
Primary melanoma	26.86 (3.49∼136.14)
Metastasis melanoma	16.24 (2∼89.45)
IL-7
Healthy donor	6.29 (1.83∼15.64)
Primary melanoma	4.80 (0.58∼17.84)
Metastasis melanoma	3.35 (0.29∼10.95)