A Novel Prognostic Nomogram for Gallbladder Cancer after Surgical Resection: A Single-Center Experience
Table 2
Univariate and multivariate Cox regression analyses for survival.
Patient characteristics
Univariate analysis
Multivariate analysis
HR (95%CI)
-value
HR (95%CI)
-value
Age
<60
1
≥60
1.484(0.826∼2.666)
0.187
Gender
Male
1
Female
1.559(0.834∼2.917)
0.164
BMI
<24
1
≥24
0.585(0.248∼1.379)
0.22
Jaundice
Absent
1
1
Present
2.182(1.105∼4.308)
<0.05
1.407(0.624∼3.175)
0.411
Diabetes mellitus
Absent
1
Present
0.917(0.362∼2.319)
0.855
Gallbladder stone
Absent
1
Present
1.199(0.676∼2.127)
0.534
AJCC stage
I ∼ IIIA
1
IIIB-IVB
3.66(1.963∼6.825)
<0.05
1.269(0.422∼3.811)
0.671
Tumor grade
High
1
Medium
7.049(0.952∼52.170)
0.056
5.707(0.731∼44.527)
0.10
Low
11.186(1.470∼85.170)
0.020
6.340(0.702∼57.291)
0.10
Lymphovascular invasion
Absent
1
1
Present
1.877(0.930∼3.787)
0.0788
1.4160(0.635∼3.156)
0.395
Perineural invasion
Absent
1
1
Present
3.949(2.189∼7.122)
<0.05
3.411(1.671∼6.963)
<0.05
Surgical margin
R0
1
1
R1
4.234(2.028∼8.839)
<0.05
3.102(1.201∼8.013)
<0.05
Liver invasion
Absent
1
1
Present
3.026(1.602∼5.718)
<0.05
3.00(1.336∼6.736)
<0.05
Lymph node positive rate
<0.28
1
1
≥0.28
3.007(1.502∼6.020)
<0.05
1.019(0.319∼3.251)
0.975
Liver resection
Absent
1
Present
0.771(0.426∼1.395)
0.39
0.3593(0.162∼0.797)
<0.05
Tumor size
<4.5
1
1
≥4.5
1.807(0.9715∼3.362)
0.061
2.660(1.248∼5.672)
<0.05
CA125
<12
1
1
≥12
2.639(1.338∼5.025)
<0.05
1.663(0.760∼3.643)
0.203
CA19-9
<58.5
1
1
≥58.5
3.539(1.936∼6.468)
<0.05
2.254(1.070∼4.745)
<0.05
CEA
<5
1
1
≥5
3.155(1.622∼6.136)
<0.05
0.558(0.237∼1.314)
0.182
BMI, body mass index; CA125, carbohydrate antigen 125; CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; the American Joint Committee on Cancer (AJCC) stage is according to the AJCC 8th edition.
