MCT4 Promotes Tumor Malignancy in F98 Glioma Cells

Figure 7

Working model of MCT4 overexpression in glioma cells. MCT4 upregulation in glioma cells increases lactate export, promoting proliferation and survival in glioma cells by modulating cell cycle regulation and cell death mechanisms. Furthermore, it leads to enhanced migration and invasiveness of glioma cells by altering actin cytoskeleton morphology. Finally, it promotes angiogenesis in surrounding blood vessels.